PUBLICATION RECORD

 

Below are publications related to the SAIRP 2001-2006.  We have also included abstracts and conference proceedings to indicate activity for base grants and R & D that have not yet seen publication.  A list of lectures provided by the PI related to small animal imaging is presented.  For peer-reviewed research, key SAIRP members are in blue and collaborators or service center users in red.  To provide a clear picture of the influence of the SAIRP at our institution, we have omitted publications that were generated by the ICMIC, even if equipment procured with SAIRP support was used to obtain the images.  All of the publications below involved extensive SAIRP input.

 

Publications specifically acknowledging the SAIRP:

 

Peer-reviewed research

 

1.  Pomper MG, Musachio JL, Zhang J, Zhou Y, Scheffel U, Hilton J, Maini A, Dannals RF, Wong DF, Kozikowski AP.  11C-MCG: Synthesis, uptake selectivity and primate PET of a probe for glutamate carboxypeptidase II (NAALADase.)   Mol Imaging 2002; 1:96-101.

 

2.  Bettegowda C, Dang LH, Abrams R, Huso DL, Dillehay L, Cheong I, Agrawal N, Borzillary S, McCaffery JM, Watson EL, Lin K-S, Bunz F, Baidoo K, Pomper MG, Kinzler KW, Vogelstein B, Zhou S.  Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.  Proc Natl Acad Sci USA 2004; 100:15083-8.

 

3.  Agrawal N, Bettegowda C, Cheong I, Geschwind J-F, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz L, Pomper M, Abusedera M, Wahl RL, Kinzler KW, Zhou S, Huso DL, Vogelstein B.  Bacteriolytic therapy can generate a potent immune response against experimental tumors.  Proc Natl Acad Sci USA 2004, 101:15171-15177.

 

4.  Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, Hullihen J, Pederson PL.  Advanced cancers:  eradication in all cases using 3-bromopyruvate therapy to deplete ATP.  Biochem Biophys Res Comm 2004, 324:269-275.

 

5.  Lin K-S, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen M-K, Pili R, Pomper MG, Carducci M, Wagner HN. A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier.  Bioconj Chem 2004, 15:1416-1423.

 

6.  Bettegowda C, Foss CA, Wang Y, Fox J, Zhou S, Kinzler K, Vogelstein B, Pomper MG.  Imaging bacterial infection in live animals with radiolabeled FIAU. Proc Natl Acad Sci USA, 2005; 102:1145-51150.  [featured on the cover of this issue and in an article in Biophotonics International 2005; 12:48]

 

7.  Pomper MG, Phillips E, Fan H, McCarthy DJ, Keith RA, Gordon JC, Dannals RF, Musachio JL.  Synthesis and biodistribution of radiolabeled a7 nicotinic acetylcholine receptor ligands.  J Nucl Med, 2005; 46:326-334.

 

8.  Lin K-S, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen M-K, Pili R, Pomper MG, Carducci M, Wagner HN. A new high affinity technetium-bombesin analogue with low abdominal accumulation.  Bioconj Chem 2005; 16:43-50.

 

9.  Foss CA, Mease RC, Fan H, Wang Y, Ravert HT, Dannals RF, Olszewski RT, Heston WD, Kozikowski AP, Pomper MG.  Radiolabeled small molecule ligands for prostate-specific membrane antigen:  in vivo imaging in experimental models of prostate cancer.  Clin Cancer Res 2005; 11:4022-4028.  [featured on the cover of this issue]

 

10.  Guilarte TR, McGlothan JL, Foss CA, Zhou Z, Heston WD, Kozikowski AP, Pomper MG.  Glutamate Carboxypeptidase II Levels in Rodent Brain using [125I]DCIT Quantitative Autoradiography.  Neurosci Lett, 2005; 387:141-144.

 

11.  Weisenberger AG, Gleason SS, Goddard J, Kross B, Majewski S, Meikle SR, Paulus MJ, Pomper M, Popov V, Smith MF, Welch BL, Wojcik R.  A restraint free small animal SPECT imaging system with motion tracking.  IEEE Trans Nucl Sci 2005; 52:638-644.

 

12.  Mathews WB, Foss CA, Stoermer D, Ravert HT, Dannals RF, Henke BR, Pomper MG.  Synthesis and biodistribution of [11C]GW7845, a positron-emitting agonist for PPARg.  J Nucl Med, 2005; 46:1719-1726.

 

13.  Diaz LA, Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, Hwang P, Vogelstein A, Garrett-Mayer E, Kobrin B, Pomper M, Zhou S, Kinzler KW, Vogelstein B, Huso D.  Pharmacologic and toxicologic evaluation of C. novyi-NT spores.  Toxicol Sci. 2005; 88:562-75.

 

14.  Hardwick MJ, Chen M-K, Baidoo K, Pomper MG, Guilarte TR.  In vivo imaging of benzodiazepine receptors in mouse lungs:  a biomarker of inflammation.  Mol Imaging  2005; 4:432-8.

 

15.  Glunde K, Foss CA, Takagi T, Wildes F, Bhujwalla ZM. Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors. Bioconjug Chem.2005;16:843-51.

 

16.  Kundu BK, Stolin AV, Pole J, Baumgart L, Fontaine M, Wojcik R, Kross B, Zorn C, Majewski S, Williams MB.  Tri-modality small animal imaging system.  IEEE Transactions on Nuclear Science 2006; 53:66-69.

 

17.  Wang Y, Seidel J, Tsui BMW, Vaquero JJ, Pomper MG.  Performance evaluation of the GE eXplore VISTA DR small animal PET scanner.  J Nucl Med 2006, in press.

 

Review articles

 

1.  Pomper MG.  Can small animal imaging accelerate drug development?  J Cell Biochem Suppl. 2002; 39:211-20.  [overlaps with Current Pharmaceutical Design article, below]

 

2.  Pomper MG, Lee JS.  Small animal imaging in drug development.  Current Pharmaceutical Design 2005; 3247-2372.  [featured on cover of this issue]

 

3.  Pomper MG.  Translational Molecular Imaging for Cancer.  Cancer Imaging 2005; 5:S16-S26.

 

Abstracts

 

1.  Pomper MG, Musachio JL, Zhang J, Rauseo P, Scheffel U, Hilton J, Kozikowski AP.  [11C]MCG:  Synthesis and Uptake Selectivity of a Probe for NAALADase.  American Association for Cancer Research, Orlando, FL, January 23-27, 2002.

 

2.  Pomper MG, Musachio JL, Zhang J, Zhou Y, Rauseo P, Scheffel U, Hilton J, Maini A, Wong DF, Kozikowski AP.  [11C]MCG: Synthesis and Uptake Selectivity of a Probe for NAALADase. 50th Annual Meeting of the Society of Nuclear Medicine, June, 2002.

 

3.  Pomper MG, Phillips E, Fan H, McCarthy DJ, Keith RA, Musachio JL.  Synthesis and biodistribution of radiolabeled a7 nicotinic acetylcholine receptor ligands.  51st Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June, 2003.

 

4.  Lee JS, Hagemann RL, Wang Y, Tsui BM, Pomper MG.  Performance Evaluation of the NIH ATLAS Small Animal PET System.  2nd Annual Meeting of the Society of Molecular Imaging, San Francisco, CA, August, 2003.

 

5.  Lee JS, Hagemann RL, Lee LA, Dang CV, Pomper MG.  Assessment of the glycolytic effects of adenovirus-mediated expression of c-myc using small animal FDG-PET.  Academy of Molecular Imaging 2003 Conference, Madrid, Spain, September, 2003.

 

6.  Lee JS, Amador ML, Hagemann RL, Hidalgo M, Pomper MG.  Treatment effects of the EGFR tyrosine kinase inhibitor OSI-774 on a mouse model of cholangiocarcinoma:  assessment by small animal FDG-PET.  Academy of Molecular Imaging 2003 Conference, Madrid, Spain, September, 2003.

 

7.  Pomper MG, Ravert HT, Zhang J, Scheffel U, Musachio JL, Dannals RF, Kozikowski AP.  New imaging agents for prostate cancer:  radiolabeled inhibitors of glutamate carboxypeptidase II (GCP II).  Academy of Molecular Imaging 2003 Conference, Madrid, Spain, September, 2003.

 

8.  Lee JS, Alvey SJ, Hagemann RL, Kuhajda FP, Gabrielson DW, Pomper MG.  Pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in lung cancer by small animal FDG-PET.  Academy of Molecular Imaging 2003 Conference, Madrid, Spain September, 2003.

 

9.  Tanhehco YC, Foss CA, Wang Y, Fox J, Pomper MG, Ambinder RF.  In vivo imaging of herpesvirus lytic gene activation.  The Eighth International Conference on Malignancies in AIDS and Other Immunodeficiencies (ICMAOI):  Basic, Epidemiologic and Clinical Research.  Bethesda, MD April, 2004.

 

10.  Bettegowda C, Foss, CA, Wang Y, Fox J, Zhou S, Kinzler K, Vogelstein B, Pomper MG.  Imaging bacteriolytic therapy in experimental tumors.  52nd Annual Meeting of the Society of Nuclear Medicine, Philadelphia, PA, June, 2004.

 

11.  Tanhehco YC, Foss CA, Wang Y, Fox J, Ambinder RF, Pomper MG.  Imaging human gammherpesvirus lytic infection in mouse models of lymphoproliferative disease.  52nd Annual Meeting of the Society of Nuclear Medicine, Philadelphia, PA, June, 2004.

 

12.  Mathews WB, Foss CA, Stoermer D, Ravert HT, Rauseo PA, Dannals RF, Henke BR, Bhujwalla ZM, Pomper MG.  Synthesis and biodistribution of [11C]GW7845, a positron-emitting agonist for PPAR-g.  52nd Annual Meeting of the Society of Nuclear Medicine, Philadelphia, PA, June, 2004.

 

13.  Foss CA, Prescher JA, Dube DH, Bertozzi CR, Pomper MG.  MicroSPECT imaging and biodistribution of azidosialic acid in mice with [125I]-FLAG-phospine.  52nd Annual Meeting of the Society of Nuclear Medicine, Philadelphia, PA, June, 2004.

 

14.  Foss CA, Mease RC, Fan H, Ravert HT, Dannals RF, Kozikowski AP, Pomper MG.  Imaging PSMA expression in prostate cancer xenografts by PET and gamma scintigraphy.  3rd Annual Meeting of the Society for Molecular Imaging, St. Louis, MO, September, 2004.

 

15.  Foss CA, Maitra A, Iacobuzio-Donahue C, Kern SE, Hruban R, Pomper MG.  [125I]Anti-claudin 4 and [125I]anti-PSCA monoclonal antibodies as novel imaging agents for human pancreatic cancer in xenograft-bearing mice.  3rd Annual Meeting of the Society for Molecular Imaging, St. Louis, MO, September, 2004.

 

16.  Zhang Y, Lal B, Reznik T, Laterra J, Pomper MG.  Imaging the hedgehog signaling pathway.  3rd Annual Meeting of the Society for Molecular Imaging, St. Louis, MO, September, 2004.

 

17.  Song H, Shahverdi K, Fox J, Cho YI, Wang Y, Gimi B, Pomper M, Tsui B, Bhujwalla Z, Reilly RT, Sgouros G.  A mouse model of breast cancer metastases for targeted alpha-particle radioimmunotherapy in the presence of cross-reactive normal organs.  96th Annual Meeting of the American Association for Cancer Research, Anaheim, CA, April, 2005.

 

18.  Ravert HT, Dorff P, Foss CA, Fan H, Holmquist CR, Phillips E, McCarthy DJ, Heys, R, Holt D, Dannals RF, Pomper MG.  Synthesis of 5’-(2-[18F]fluorophenyl)-spiro[1-azabicyclo[2.2.2]octane]-3,2’(3’H)-furo[2,3-b]pyridine ([18F]FPS), an agonist at the a7 nicotinic acetylcholine receptor.  J Labelled Compd Radiopharm 2005: 48, S168.

 

19.  Foss CA, Dusich C, Mease RC, Maitra A, Pomper MG.  Synthesis and validation of a novel small-molecule fluorescent probe for PSMA expression in human tumor neovasculature.  Molecular Imaging 2005; 4:S321.

 

20.  Foss CA, Prescher J, Dube D, Bertozzi CA, Pomper MG.  Synthesis and biodistribution of azido-reactive [125I]phos-BH:  a novel probe for sialic acid expression for use with PET and SPECT.  Molecular imaging 2005; 4:S283.

 

21.  Fu D-X, Lemas V, Foss CA, Tanhehco Y, Cheng C, Tei S, Ambinder R, Pomper MG.  Imaging lytic induction in EBV-associated tumors in vivo.  Molecular Imaging 2005; 4:S299.

 

22.  Zhang Y, Laterra J, Pomper MG.  Imaging modulation of hedgehog signaling in vivo.  Molecular imaging 2005; 4:S299.

 

23.  Warlick CA, Chowdhury W, De Marzo AM, Pomper MG, Isaacs WB, Rodriguez RR.  Toward a-methylacyl coenzyme A racemase (AMACR)-mediated molecular imaging in prostate cancer.  National Medical Association 2005 Convention.

 

24.  Wang Y, Tsui B, Seidel J, Fox J, Pomper MG.  Performance evaluation of the GE eXplore Vista preclinical PET scanner.  Molecular Imaging 2005; 4:S259.

 

25.  Mahadevappa M, Cho YI, Pomper MG.  Performance evaluation of X-ray CT as part of SPECT-CT system used for small animal imaging.  Molecular Imaging 2005; 4:S260.

 

26.  Endres CJ, El-Dieb A, Li F, Lee L, Pomper MG.  Visualizing the effect of c-myc expression on glucose uptake and metabolism.  Molecular Imaging 2005: 4:S295.

 

27.  Endres CJ, Ravert H, Dorff P, Foss CA, Fan H, Holmquist C, Phillips E, McCarthy D, Heys R, Holt D, Dannals RF, Pomper MG.  [18F]M665017, a new imaging probe for a7 nicotinic receptors.  Molecular Imaging 2005: 4:S338.

 

28.  Fu D, Lemas V, Foss CA, Fox J, Pomper MG, Ambinder RF.  Enzymatically-targeted 131I-therapy for herpesvirus associated malignancies.  ASCO, 2006.

 

29.  Endres CA, Seidel J, Foss CA, Fox J, Pomper MG.  Mouse dosimetry using small animal PET.  NRM06 - 6th Neuroreceptor Mapping Symposium, July 6-8, 2006, Copenhagen, Denmark.

 

Publications under review (journal of submission)

 

1.  Foss CA, Fox J, Feldman G, Maitra A, Iacobuzio-Donahue C, Kern SE, Hruban R, Pomper MG.  Radiolabeled anti-claudin 4 and anti-PSCA:  initial imaging in experimental models of pancreatic cancer.  (Molecular Imaging, 2006)

 

2.  Fu D-X, Tanhehco YC, Chen J, Foss CA, Fox J, Lemas V, Chong J-M, Ambinder RF, Pomper MG.  Tumor imaging by induction of endogenous viral gene expression.  (Nature Medicine, 2006)

 

3.  Holt DP, Ravert HT, Dannals RF, Pomper MG.  Synthesis of [11C]gefitinib for imaging epidermal growth factor receptor tyrosine kinase with positron emission tomography.  (Journal of Labelled Compounds and Radiopharmaceuticals, 2006)

 

4.  Ishimori T, Tatsumi M, Pomper MG, Wahl RL.  Feasibility of radiolabeled paclitaxel to predict response to taxane chemotherapy:  in vitro evaluation.  (Journal of Nuclear Medicine, 2006)

 

5.  McGrath-Morrow S, Laube B, Tzou S-C, Cho C, Cleary J, Kimura H, Rose NR, Caturegli P.  IL-12 over-expression in mice as a model for Sjogren’s lung disease.  (American Journal of Pathology, 2006)

 

Publications utilizing SAIRP personnel and/or resources [relationship indicated, where necessary]:

 

Peer-reviewed research

 

1.  Ravert HT, Kleckner RW, Collins J, Mathews WB, Pomper MG, Wahl R, Dannals RF.  Radiosynthesis of [11C]paclitaxel.  J Labeled Compds Radiopharm 2002; 45:471-47.

 

2.  McElroy DP, MacDonald LR, Beekman FJ, Wang YC, Patt BE, Iwanczyk JS, Tsui BMW, Hoffman EJ, Performance evaluation of A-SPECT:  a high resolution desktop pinhole SPECT system for imaging small animals, IEEE Trans. Nucl Science 2002; 49:2139-2147.

 

3.  Tatsumi M, Nakamoto Y, Traughber B, Marshall LT, Geschwind J-FH, Wahl RL.  Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18]fluoro-2-deoxy-D-glucose.  Cancer Res 2003; 63:6252-6257.

 

4.  Olson LE, Bedja D, Alvey SJ, Gabrielson KL, Reeves R. Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase.  Cancer Res 63:6602-6606, 2003.  [small animal ultrasound]

 

5.  Segars WP, Tsui BMW, Frey EC, Johnson GA, Berr SS.  Development of a 4-D digital mouse phantom for molecular imaging research. Mol. Imaging and Biol 2004; 6:149-159.

 

6.  Pani R, Pellegrini, R, Cinti MN, Trotta C,  Bennati P,  Betti M, De Vincentis G,  Cusanno F,  Garibaldi F,  Ridolfi S,  Majewski S and  Tsui BMW.  New devices for imaging in nuclear medicine, Cancer Biother and Radiopharm 2004; 19: 121-128.

 

7.  Pointek KB, Huso D, Grinberg A, Westphal H, Gabrielson KL, Bedja D, Germino GG. A functional floxed Pkd1 allele. Am Soc Nephrol 2004;15:3035-3043. [small animal ultrasound for phenotyping]

 

8.  Ng CM, Cheng A, Myers LA, Martinez-Murillo F, Jie C, Bedja D, Gabrielson KL, Hausladen JM, Mecham RP, Judge DP, Dietz HC.  TGFβ-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome.  J Clin Invest 2004 114:1586-92.  [small animal ultrasound for phenotyping]

 

9.  Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson KL, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006; 312:117-21.  [small animal ultrasound for phenotyping]

 

10.  Wachtman L, Bedja D, Pin S, Browning M, Gabrielson K.  Validation of the use of long-term indwelling jugular catheters in model of cardiotoxicity, Contemporary Topics in Laboratory Animal Science 2006, in press.  [small animal ultrasound]

 

Review articles

 

1.  Zhou J, Neale JH, Pomper MG, Kozikowski AP.  NAAG Peptidase inhibitors and their potential for diagnosis and therapy.  Nat Rev Drug Discovery, 2005; 4:1015-26.

 

2.  Pomper MG.  Molecular imaging: an overview.  Acad Radiol 2001; 8:1141-53.

 

3.  Pomper MG, Hammoud, DA.  Positron emission tomography in molecular imaging:  could the promise of personalized patient care be reaching fruition?  IEEE Engineering in Medicine and Biology 2004; 23:28-37.

 

4.  Scheffel U, Pomper MG.  PET imaging of GRP receptor expression in prostate cancer.  J Nucl Med 2004; 45:1277-78.  [Editorial]

 

Abstracts

 

1.  Nakamoto Y, Ravert HT, Hilton J, Traughber BJ, Tatsumi M, Scheffel U, Dannals RF, Pomper MG, Collins JM, Wahl, RL.  Dosimetry and stability evaluation of 11C-paclitaxel.   50th Annual Meeting of the Society of Nuclear Medicine, June, 2002.

 

2.  Ishimori T, Tatsumi M, Nakamoto Y, Ravert HT, Pomper MG, Wahl RL.  Feasibility of C-11 paclitaxel to predict response to taxane chemotheraphy:  pre-clinical evaluation.  52nd Annual Meeting of the Society of Nuclear Medicine, Philadelphia, PA, June, 2004.

 

3.  Tsui BMW, Qi Y, Wang Y, Mok SP, Yoder B, Fox J, Li J, Pomper MG.  Experience with a X-SPECT small animal imaging system with a high-resolution detector.  3rd Annual Meeting of the Society for Molecular Imaging, St. Louis, MO, September, 2004.

4.  Mok GSP, Wang Y, Tsui BMW. Design of a novel pinhole collimator system for SPECT iImaging of small animals with different sizes. Paper presented at the 2005 IEEE Nuclear Science Symposium and Medical Imaging Conference, October 23-29, 2005, Puerto Rico.

 

5.  Tsui B, Wang Y, Mok S-P, Walz-Flannigan A, Fox J, Pomper MG.  High performance pinhole SPECT for cardiovascular imaging in small animals.  Molecular Imaging 2005: 4:S269.

6.  Mok GSP, Wang Y, Li J, Wagenaar DJ, Tsui BMW. Investigation of multi-pinhole collimator designs and imaging reconstruction methods for imaging small animals with different sizes using a SPECT/CT Imaging system. Paper presented at the 2nd Biannual Workshop on Small-Animal SPECT Imaging, Tucson Arizona, USA, March 8-10, 2006.

7.  Tsui BMW, Wang Y, Mok SP, Walz-Flannigan A, Smith MF and Majewski S, Design considerations of a high-resolution and high-sensitivity multi-pinhole SPECT system for small animal imaging.  Paper presented at the 2nd Biannual Workshop on Small-Animal SPECT Imaging, Tucson Arizona, USA, March 8-10, 2006.

8.  Walz-Flannigan A, Mok SP, Wang Y, Gabrielson K, Fox J, Foss C, Nimmagadda S, Seshadri M, Pomper MG, and Tsui BMW, Monitoring the growth of atheromatous plaques in ApoE-/- mice using Tc99m-HYNIC-annexin-V SPECT imaging techniques.  Paper presented at the 2nd Biannual Workshop on Small-Animal SPECT Imaging, Tucson Arizona, USA, March 8-10, 2006.

9.  Mok GSP, Wang Y, Li J, Patt B, Tsui BMW. Development and evaluation of a novel multi-pinhole collimator system for imaging small animals with different sizes using a FLEX MicroSPECT/CT imaging system.  Paper accepted for presentation at the 53rd Annual Meeting of the Society of Nuclear Medicine, San Diego, USA, June 3-7, 2006.

 

Conference proceedings

 

1.  Qi YJ, Tsui BMW, Frey E. and Yoder B., Characteristics of compact detectors based on pixellated NaI(Tl) crystal arrays, Conference Record: M10-164, IEEE Nuclear Science Symposium and Medical Imaging Conference, 2002.

 

2.  Qi YJ, Tsui BMW, Wang Y, Yoder B, Wojcik R, Majewski S, Performance characteristics of a new modular camera based on pixellated crystal for high-resolution pinhole SPECT with comparison to a standard camera with continous crystal, Conference Record: M7-60, IEEE Nuclear Science Symposium and Medical Imaging Conference, 2003.

 

3.  Wojcik R, Goode AR, Smith M Beller, GA, Ellman P, Glover DK, Majewski S, Qi YJ, Tsui BMW, Wang Y, Weisenberger AG, Dedicated small field of view SPECT camera based on a 5" PSPMT and crystal scintillator array for high resolution small animal cardiac imaging, Conference Record: M3-43, IEEE Nuclear Science Symposium and Medical Imaging Conference, 2003.

 

4.  Pellegrini R, Pani R, Cinti MN, Trotta C, Iurlaro G, Betti M, Bennati P, Cusanno F, Garibaldi F, Ridolfi S, Mattioli M, Majewski S and Tsui BMW.  Design of Compact Pinhole SPECT System based on Flat Panel PMT.  Conference Record: page 1173, IEEE Nuclear Science Symposium and Medical Imaging Conference, 2003.

 

5.  Weisenberger AG, Majewski S, Popov V, Welch BL, Wojcik R, Goddard JS, Gleason SS, Paulus MJ, Pomper M.  Development and Testing of a Restraint Free Small Animal SPECT Imaging System with Infrared Based Motion Tracking.  Conference Record of the 2003 IEEE Nuclear Science Symposium and Medical Imaging Conference, Portland, 2003.

 

6.  Weisenberger AG, Kross B, Majewski S, Popov V, Smith MF, Tran VH, Welch B, Wojcik R, Gleason S, Paulus M, Meikle SR, Pomper M.  Two 10 x 10 cm detector heads for a restraint free small animal SPECT imaging system.  Conference Record of the 2004 IEEE Nuclear Science Symposium and Medical Imaging Conference, Rome, Italy, October, 2004.

 

7.  Weisenberger AG, Baba JS, Kross B, Gleason SS, Goddard J, Majewski S, Meikle SR, Paulus MJ, Pomper MG, Popov V, Smith BL, Welch B, Wojcik.  Dual Low Profile Detector Heads for a Restraint Free Small Animal SPECT Imaging System.  Conference Record of the 2004 IEEE Nuclear Science Symposium and Medical Imaging Conference, Rome, 2004.

 

Book chapters

 

1.  Tsui BMW, Wang Y, Qi Y, Sawyer S, Frey EC, Majewski S, and Pomper MG.  Feasibility of microSPECT/CT imaging of plaques in a transgenic mouse model. (In) Small Animal SPECT Imaging, Kupinski MA and Barrett HH, editors, (Springer), pp 215-224, 2005.

 

2.  Qi Y, Tsui BMW, Wang Y, Yoder B, Wojcik R, Majewski S and Weisenberger AG. Development and characterization of a high-resolution microSPECT system for small animal imaging. (In) Small Animal SPECT Imaging, Kupinski MA and Barrett HH, editors, (Springer), pp 259-266, 2005.

 

Publications under review (journal of submission)

 

1.  Gabrielson K, Bedja D, Pin S, Gama L, Yuan B, Muratore N. Increased erbB2 is an early response to Doxorubicin-induced Cardiac Injury.  (Cancer Research, 2006)

 

Successful grant applications with SAIRP input:

 

Zaver Bhujwalla:  P50CA103175 – JHU ICMIC Program (JHU, 08/10/03-07/31/08)

 

T-C Wu:  P50CA098252 – SPORE in Cervical Cancer (JHU, 09/30/03-08/21/08)

 

Benjamin Tsui:  R01EB001558 – High-Resolution SPECT for Molecular Imaging (JHU, 09/30/04-08/31/08)

 

Martin Pomper:  R21CA111982 – PSMA-based PET Ligands for Prostate Cancer Imaging (JHU, 04/07/06-03/31/08)

R21CA114111 – PSMA-based SPECT Tracers for Prostate Cancer Imaging (JHU, 05/01/06-04/30/08)

R21EB005324 – PSMA-based Gene Reporter-Probe System (RMI) (JHU, 09/15/05-08/31/09)

DoDPC050825 – PSMA-based PET Ligands for Prostate Cancer Imaging (JHU, 12/01/05-11/30/07)

Pilot project on SPORE in Lymphoma.

Pilot project on SPORE in Cervical Cancer.

Patrick C. Walsh Foundation (JHU – for human studies of [18F]DCFBC for prostate cancer imaging)

Alliance for Science and Technology Development (JHU – for human studies of [124I]FIAU for imaging lytic induction cancer therapy and bacterial infection)

 

Anirban Maitra:  R01CA113669 – Hedgehog Inhibitors in Pancreatic Cancer (JHU, 04/01/05-03/31/10)

 

Paras Prasad:  R01CA119397 – Multifunctional Nanoparticles in Diagnosis and Therapy (SUNY, Buffalo, 09/29/05-08/31/10)

 

Catherine Foss:  DoDPC050999 – Fluorescent and Radiolabeled Small Molecule Ligands for Prostate-Specific Membrane Antigen:  In Vivo Imaging in Experimental Models of Prostate Cancer (JHU, 10/01/2005-9/30/06)

 

John Laterra:  Dana Foundation – Transcription Factor Activity Imaging in Brain and Brain Tumors  (Kennedy Krieger Institute of JHU, 01/01/05 - 12/31/06)

     

Eric Ford:  JHU Institutional Research Grant:  Spatial distribution of hypoxia and response to localized radiotherapy (2006)

 

Pending grant applications with SAIRP input (estimated):

 

Martin Pomper:  GCPII-based Brain Imaging Agents (NIH R21/R33).

 

Akhilesh Pandey:   A targeted proteomic approach to identify and validate membrane proteins as biomarkers for early detection of pancreatic cancer (Lustgarten Foundation).

 

Richard Ambinder:  Enzymatic radiotherapy (V Foundation).

 

Mark Castaneres:  (graduate student – pharmacology, Kirschstein National Research Service Award Individual Fellowship).

 

Shibin Zhou:  Combination Bacteriolytic Colon Cancer Therapy (project on GI SPORE competing renewal).

 

Christopher Endres:  STTR – Automated Small Animal Blood Sampler for Imaging Studies (with Bioanalytical Systems, Inc (BASi))

 

Patents or patent applications:

 

Pomper MG, Zhang J, Kozikowski AP, Musachio JL.  Imaging agents and methods of imaging NAALADase of PSMA.  WO 03/060523 A1, January 24, 2003.  Licensed to:  Molecular Insight, Inc.

 

Pomper MG, Bettegowda C, Zhou S, Kinzler K, Vogelstein B.  Imaging bacteria with light-emitting substrates of thymidine kinase.  Pending 20 June 2004.

 

Mease RC, Foss CA, Dusich C, Pomper MG.  A Multifunctional Intermediate for Imaging PSMA.  Provisional filed May 10, 2005.

 

Pomper MG, Mease RC, Lupold SE, Rodriguez R.  A PSMA-based Gene Reporter-probe Syste